Back to Insights and Updates for ProvidersMay 2025

Concurrent Use of Opioids and Benzodiazepines tip sheet

All products

When used together, opioid medications to treat pain and benzodiazepines prescribed for anxiety, insomnia, or other conditions can put an individual at greater risk of overdose. Both drug classes act as central nervous system depressants that when combined, can lead to sedation and dangerously low breathing rates, or even cessation of breathing.

Because of this significant risk, the concurrent use of opioids and benzodiazepines is strongly discouraged, especially among older adults who have increased sensitivity to benzodiazepines and decreased metabolism of long-acting agents.

As part of Medicare Star Ratings, the Centers for Medicare and Medicaid Services (CMS) has a measure aimed at assessing and discouraging the concurrent use of opioids and benzodiazepines. Our new Concurrent Use of Opioids and Benzodiazepines (COB) Star Measure tip sheet includes an overview of that measure along with information and guidance for providers to consider before prescribing these medications for patients.

All Point32Health’s Star Measure tip sheets outline key features of specific Medicare Star Rating program measures. These best practices and tips can optimize Star Ratings and identify opportunities to improve patient care. For the full collection of Point32Health Star Measure and HEDIS® tip sheets currently available, refer to the HEDIS and Star Rating tip sheets page on our provider website.

HEDIS® is a registered trademark of the National Committee for Quality Assurance (NCQA).